Faculty Opinions recommendation of A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic…

By Julian Parkhill. 2006

416 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/66d84c2241749f9fdcbfed0484e8b24454bb5b5b

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Citations in the corpus

CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity (2014, background): “Noteworthy, the RNA recognition motif is widespread in manyCas proteins, andmost of theCas families of proteins carry functional domains that interact with nucleic acids, such as DNA binding, RNA binding, helicase, and nuclease motifs (Makarova et al., 2002, 2006, 2011a, 2011b, and 2013).”
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex (2009, neutral): “1Departments of Biochemistry and Molecular Biology 2Department of Genetics University of Georgia, Athens, GA 30602, USA 3Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 060”
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea (2010, positive): “This possibility, which was supported by a detailed bioinformatic analysis of the cas genes that revealed a bias towards proteins that are predicted to facilitate transactions among nucleic acids, led to the proposition that CRISPR immunity could function in a manner analogous to eukaryotic RNA”
Regulatory RNAs in Bacteria (2009, background): “These findings, together with the observation that some CAS genes encode proteins with functions potentially analogous to eukaryotic RNAi enzymes (Makarova et al., 2006), have led to a model for CRISPR RNA function (Figure 3).”
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome (2006, background): “Indeed, a recent analysis has indicated potential analogies between the CRISPR system and the RNA interference (RNAi) mechanisms of eukaryotes, suggesting that they may form part of an RNA-mediated 'immune system”
Short motif sequences determine the targets of the prokaryotic CRISPR defence system. (2009, background): “, 2005) and the CRISPR/CAS system (CASS) versions (Makarova et al., 2006).”
PILER-CR: Fast and accurate identification of CRISPR repeats (2007, methodology): “1), many of them can be found relatively easily using ad hoc software tools [2,6] or existing software tools such as Reputer [8], as used in [5], and PatScan [9], as used in [10].”
Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, neutral): “Several hypotheses were raised, including thoughts that CRISPR spacers act as small RNA guides to degrade viral transcripts in a RNAi-like mechanism (Makarova et al., 2006) or that CRISPR spacers direct Cas enzymes to cleave viral DNA at spacer-matching regions (Bolotin et al.”
The Biology of CRISPR-Cas: Backward and Forward. (2018, neutral): “These parameters are lower in thermophilic environments, potentially explaining the enrichment of CRISPR-Cas in thermophiles (Makarova et al., 2006).”
The new frontier of genome engineering with CRISPR-Cas9 (2014, neutral): “Genetic studies showed that S. thermophilus Cas9 is essential for defense against viral invasion ( 45 , 66 ), might be responsible for introducing DSBs into invading plasmids and phages ( 67 ), enables in vivo targeting of temperate phages and plasmids in bacteria ( 66 , 68 ), and requires the HNH a”