The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
By M. Sebaihia, B. Wren, P. Mullany, N. Fairweather, N. Minton, R. Stabler, N. Thomson, A. Roberts, A. Cerdeño-Tárraga, Hongmei Wang and 29 more. Nature Genetics, 2006
933 citations recorded by the source corpus.
Subfields: Immunology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/ff5b42443c8e378f95e78b628fd94215aa5fb8b0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
Citations in the corpus
- Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores (2008, background): “Homologs of GerA, GerB, and GerK exist in several Bacillus species as well as in many Clostridium species but are absent in C. difficile, suggesting that C. difficile responds to different kinds of environmental cues (26, 33 ).”
- The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes (2014, result): “The core genome represented 40% of the P. difficile 630 reference genome, consistent with previous findings [94].”
- The human gut virome: inter-individual variation and dynamic response to diet. (2011, background): “diversity of lysins (Seo et al. 2010), holins (Wang et al.”
- CRISPR-Cas Systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea (2013, background): “Although most CRISPRs are located in chromosomal regions, sometimes within proviral-like elements (Sebaihia et al. 2006), repeat arrays are also found on plasmids, an important vehicle of horizontal gene transfer, at least for some bacteria (Godde and Bickerton 2006; Chakraborty et al. 2010).”
- Emergence of Clostridium difficile-associated disease in North America and Europe. (2006, neutral): “difficile strain 630 was published recently [24].”
- ClonalFrameML: Efficient Inference of Recombination in Whole Bacterial Genomes (2015, neutral): “In a gene-by-gene approach, for example [66], one can scaffold local alignments using a reference genome to obtain a whole-genome alignment.”
- The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli (2011, background): “In addition, mobile genetic elements such as insertion sequences are usually located in the vicinity of CRISPR/ Cas systems, while some CRISPR/Cas systems are located on large plasmids (>40 kb) (29) and even prophages (34).”
- Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “difficile strain shows a large proportion of the genome with mobile genetic elements putatively responsible for the acquisition of genes involved in resistance and virulence.([478]) The cdeA gene from a clinical C.”