Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

By N. Rogers, E. Slack, A. Edwards, M. Nolte, O. Schulz, E. Schweighoffer, David L. Williams, S. Gordon, V. Tybulewicz, Gordon D. Brown and 1 more. Immunity, 2005

973 citations recorded by the source corpus.

Subfields: Immunology, Plant Science

View Paper: https://www.semanticscholar.org/paper/66473ee69c7cf22d5eb7728c81b68c231e8306f8

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Citations in the corpus

An integrated model of the recognition of Candida albicans by the innate immune system (2008, background): “The cytoplasmic tail of dectin 1 contains an immunoreceptor tyrosine-based activation-like motif (ITAM), which can mediate various protective responses through spleen tyrosine kinase and caspase recruitment domain protein 9 ( Syk – CARD9 )-dependent pathways, such as the stimulation of interleukin 2”
Protein-glycan interactions in the control of innate and adaptive immune responses (2008, background): “In contrast, dectin-1, a Ca 2+ -independent CLR, is specific for β-glucan, a fungus-specific glyca”
Pattern recognition receptors and control of adaptive immunity (2009, background): “Interestingly, the signaling pathways used by Dectin-1 are very similar to those engaged by the antigen receptors in lymphocytes and are distinct from those used by TLRs (35, 37).”
Dectin-1 is required for β-glucan recognition and control of fungal infection (2006, background): “and the production of many cytokines and chemokine”
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans (2007, result): “However, we did find that zymosan-induced IL-10 production was much lower in dectin-1-knockout BMDCs and thioglycollate-elicited macrophages, which was consistent with a report that DCs deficient in Syk, a protein kinase 'downstream' of dectin-1, do not produce any IL-10 but instead produce IL-12 af”
The effects of β-glucan on human immune and cancer cells (2009, background): “They are NF-κB (through Syk-mediate pathway), signaling adaptor protein CARD9 and nuclear factor of activated T cells (NFAT) [39-41] (Fig.”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “The canonical ITAM domain contains a tandem repeat YxxL/I, whereas the intracellular tail of Dectin-1 possesses only one YxxL motif (122).”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Signaling through a hemITAM by recruitment of the tyrosine kinase Syk was first described for the receptor Dectin-1 (CLEC7A) expressed in myeloid cells (74).”
Coronavirus infections and immune responses (2020, background): “The second type is to activate the receptor by activating HAM‐like motifs in the intracellular tail of the receptor, such as Dectin‐1 (CLEC7A) and DNGR‐1 (CLEC9A).(28,29) Both mechanisms”