Coronavirus infections and immune responses
By Geng Li, Yaohua Fan, Yan-ni Lai, Tiantian Han, Zonghui Li, Peiwen Zhou, Pan Pan, Wenbiao Wang, Dingwen Hu, Xiaohong Liu and 2 more. Journal of Medical Virology, 2020
1,676 citations recorded by the source corpus.
Coronaviruses (CoVs) are by far the largest group of known positive‐sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV‐induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.
Subfields: Immunology, Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c72809a82e8d35f7e09f288f1c716a499fb6b192
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Citations in the corpus
- Interleukin‐6 in Covid‐19: A systematic review and meta‐analysis (2020, background): “Coronaviruses have been observed to activate excessive and dysregulated host immune responses which may contribute to the development of acute respiratory distress syndrome (ARDS).(18,19) Autopsy analyses of patients with Covid-19 complicated by ARDS reveal hyperactivation of cytotoxic T-cells, with”
- Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients (2020, background): “Importantly, COVID-19 patients have developed characteristic pulmonary ground glass changes on imaging and peripheral lymphocytes decreasing 14, 16, 17 .”
- The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system (2020, neutral): “These findings could be somehow expected in view of the well-known role of chemokines in viral infections.”
- Immune Response, Inflammation, and the Clinical Spectrum of COVID-19 (2020, background): “Importantly, the main early defense mechanism of the infected cell is the production of type-I and type -III IFN and, although coronaviruses are sensitive to their anti-viral effects, they are able to inhibit its induction (16, 20, 52, 55).”
- Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths (2020, neutral): “Thus, clinical use of corticosteroids in the treatment of COVID-19 was not recommended in the interim, unless indicated for another reason.(44,45)”
- Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues (2020, background): “Adaptive and innate immune responses play an important role in fighting off invading coronavirus, even though they may induce a cytokine storm, which is responsible for the immunopathological damage in patients with coronavirus infections [17].”
- Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms (2020, neutral): “15 Therefore, caution should be exercised for suspected patients with COVID-19 who had normal body temperatures and visited various outpatient clinics for non-respiratory symptoms.”
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response (2020, neutral): “Each of the PRRs could induce a different biological response to subsequent protein activation [23,26].”