Krüppel-like factor 4 regulates macrophage polarization.
By Xudong Liao, N. Sharma, F. Kapadia, Guangjin Zhou, Yuan Lu, H. Hong, K. Paruchuri, Ganapati H. Mahabeleshwar, E. Dalmas, N. Venteclef and 8 more. Journal of Clinical Investigation, 2011
724 citations recorded by the source corpus.
Subfields: Hematology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0a9ff3c99a0f9eb2f982329515c5fa7659f435ca
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In Molecular Biology
Citations in the corpus
- Novel Markers to Delineate Murine M1 and M2 Macrophages (2015, background): “We found commonly up-regulated genes including TF Klf4, known to be required for inflammatory monocyte differentiation [48], and previously reported in both M1 [49] and M2 macrophages [50].”
- INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, neutral): “In addition, impaired AAM polarization due to myeloid KLF4 deficiency promoted insulin resistance (30).”
- Macrophages in immunoregulation and therapeutics (2023, background): “Meanwhile, KLF4, downstream of STAT6, was generated in the M2 macrophage, forming a feedback loop to promote the M2 genetic program ongoing.(213) Knights et al.”
- Kupffer Cells in the Liver (2013, neutral): “…studies have begun to elucidate the specific transcription factors that regulate the switch, including signal transducers and activators of transcriptions (STATs), perox-isome proliferator-activated receptor (PPAR) family members, hypoxia-inducible factor 2 α and Kruppel-like factor 4 (68,70,76).”
- Macrophage phenotypes in atherosclerosis (2014, background): “Kr€ uppel-like transcription factor 4 (KLF4), a member of the zinc finger family of transcription factors, induces the expression of M2 markers (Arg1, MR, Fizz1, and PPARc) through STAT-6 signaling and inhibits M1 polarization by sequestering NF-jB cofactors in murine macrophages (98).”
- Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “Macrophage M2 phenotype is promoted by several transcription factors, including peroxisome proliferator activated receptor γ (PPARγ) (39, 40) and Krueppel-like factor 4 (KLF-4) (41).”
- Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “Adipose tissue macrophages (ATMs) are a major component of adipose tissue and are important players in obesity-associated pathology.”