Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

By Eva Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto. Nature Immunology, 2007

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Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020 (2020, background): “Therefore, DCs are critical cells that are adept at bridging the innate and adaptive immune systems as they will di ﬀ erentiate after PRP platelet-derived growth factors are released [117].”
The inflammasomes: guardians of the body. (2009, background): “In humans, IL-1 also promotes the expansion of IL-17-secreting memory CD4+ T cells (228, 229).”
The IL-1 family: regulators of immunity (2010, background): “Recently, a key role for IL-1 in the differentiation of T H 17 cells from naive precursors, as well as in the promotion of IL-17- and IL-22-producing memory T cell recall responses in both mice and humans, has been suggeste”
A mechanism for the initiation of allergen-induced T helper type 2 responses (2008, background): “T H -17 differentiation is controlled by DC-derived IL-6 and transforming growth factor-β released from an unknown source and by IL-23 produced by DCs after dectin-1 activatio”
IL-17 and Th17 Cells. (2009, background): “In 2007, several studies claimed that TGF-β was dispensable for the differentiation of human Th17 cells (26, 27).”