The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.

By Markus Landthaler, A. Yalçin, Thomas Tuschl. Current Biology, 2004

925 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/647074e79f7df3ceb352f779128fd1f4b62cbd42

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In Cancer Research

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Gregory J. Hannon
5. Richard I. Gregory
6. Scott M. Hammond
7. R. Parker
8. Jin-Wu Nam

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Gregory J. Hannon
5. Gunter Meister
6. Richard I. Gregory
7. Yukihide Tomari
8. R. Parker

Citations in the corpus

• Perspective: machines for RNAi. (2005, background): “GENES & DEVELOPMENT 521 Landthaler et al. 2004), but Drosha and Pasha are believed to function in the nucleus, whereas miRNA loading into RISC is thought to be cytoplasmic.”
• A human snoRNA with microRNA-like functions. (2008, methodology): “(C) FH-DGCR8 or untreated cells were immunoprecipitated using anti-FLAG antibodies.”
• Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. (2006, background): “Drosha and its cofactor, DGCR8 (Gregory et al., 2004; Han et al., 2004; Landthaler et al., 2004) (known as Pasha in D.”
• The role of PACT in the RNA silencing pathway (2006, background): “…Molecular Biology Organization |All Rights Reserved 0261-4189/06 www.embojournal.org The EMBO Journal VOL 25 | NO 3 | 2006 &2006 European Molecular Biology Organization EMBO THE JOURNAL 522 pri-miRNAs into pre-miRNAs (Denli et al, 2004; Gregory et al, 2004; Han et al, 2004; Landthaler et al, 2004).”
• TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “, 2003) and its cofactor DGCR8/Pasha (Denli et al., 2004; Gregory et al., 2004; Han et al., 2004; Landthaler et al., 2004).”
• Processing of intronic microRNAs (2007, background): “Drosha functions as a complex called ‘Microprocessor’ that also contains a double-stranded RNAbinding protein, DGCR8 (also known as Pasha in flies and nematodes) (Denli et al, 2004; Gregory et al, 2004; Han et al, 2004; Landthaler et al, 2004).”
• MicroRNAs in development and disease. (2011, background): “The pri-miRNA is cleaved in the nucleus at the base of the stem-loop structure by the RNAse III enzyme Drosha (344) and its partner DGCR8/Pasha (139, 216, 229, 330) (FIGURE 1), which have been shown to require an intact secondary structure of the pri-miRNA for efficient processing (230).”