Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.

By S. Rabot, Mathieu Membrez, A. Bruneau, P. Gérard, T. Harach, M. Moser, F. Raymond, R. Mansourian, C. Chou. The FASEB Journal, 2010

607 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/63646112d388ddf658603fe7982d406581e55eeb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Liping Zhao
2. Herbert Tilg

In Physiology

1. Patrice D Cani
2. Rob Knight
3. F. Bäckhed
4. N. Delzenne
5. A. Neyrinck
6. Herbert Tilg
7. Liping Zhao
8. Robert Caesar

Citations in the corpus

• Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota (2017, background): “Next we studied whether the di ff erences in gut microbiota composition in CONVR-APPPS1 mice compared to CONVR-WT mice are the results of di ff erences in metabolic parameters 15 .”
• Proteobacteria: A Common Factor in Human Diseases (2017, background): “In fact, GM mice are usually resistant to HFD-induced obesity [33, 34].”
• Gut microbiome, obesity, and metabolic dysfunction. (2011, background): “In addition to regulating insulin sensitivity, the presence or absence of a microbial flora might also regulate cholesterol metabolism (77).”
• Dietary lipids, gut microbiota and lipid metabolism (2019, background): “microbiota in mice on a high-fat diet [31].”
• An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice (2012, background): “Previous studies show that germfree mice are resistant to HFD-induced obesity (Backhed et al., 2007; Ding et al., 2010; Rabot et al., 2010).”
• Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (2017, positive): “Gut Microbiota Contribute to the Beneficial Effects of EODF on DIO Mice Gut microbiota play a critical role in energy metabolism and lipid homeostasis, and germfree or microbiota-depleted rodents have decreased susceptibility to diet-induced obesity andmetabolic syndrome (B€ ackhed et al., 2007; Rab”
• Lentil (Lens culinaris L.): A prebiotic-rich whole food legume (2013, background): “…mineral absorption, decrease risk of colon cancer (Burns & Rowland, 2000; Conlon et al., 2012; Rowland, 2009), and decrease risk factors associated with obesity and metabolic 1 7012315171. havarajah). rights reserved. syndrome (Brugman et al., 2004; Caselato et al., 2011; Rabot et al., 2010).”
• Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “develop obesity [72,78], yet an obese microbiota induces obesity in GF mice [59].”
• Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity (2012, background): “More recently, it was shown that germ-free mice did not develop inflammation following a high-fat diet, further supporting the role of gut microbiota in low-grade inflammation onset.(23) Different studies have proposed that saturated fatty acids promote low-grade inflammation and insulin resistance ”
• Effects of diurnal variation of gut microbes and high fat feeding on host circadian clock function and metabolism (2015, result): “Compared to SPFmice, GFmice fed HF also exhibited reduced gonadal fad pad and liver weight (Figures S1C and S1D), reflecting resistance to DIO, as previously shown (Bäckhed et al., 2007; Rabot et al., 2010).”
• Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish (2012, background): “…2004, 2007; Martin et al., 2009), which do not distinguish between exogenous and endogenous lipid sources, and serum chylomicrons (Velagapudi et al., 2010) or fecal crude fat (Yoshida et al., 1968; Rabot et al., 2010), which do not do not distinguish between dietary and microbe-produced lipids.”
• Targeting gut microbiota in obesity: effects of prebiotics and probiotics (2011, background): “However, the energy spared by fermentation is not sufficient to explain why mice with normal gut microbiota that were fed with a high-carbohydrate, high-fat diet developed more adipose tissue and exhibited a greater glucose intolerance than germ-free mice that were fed the same diet”