Proteobacteria: A Common Factor in Human Diseases
By G. Rizzatti, Loris Riccardo Lopetuso, G. Gibiino, C. Binda, Antonio Gasbarrini. BioMed Research International, 2017
1,108 citations recorded by the source corpus.
Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases.
Subfields: Food Science, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e4af90c3fbc8c1694456facdfa4afcd3cb0ff6c6
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Citations in the corpus
- What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases (2019, positive): “Other studies [50,88] confirmed the role of Proteobacteria in obesity by producing pro-inflammatory molecules such as lipopolysaccharides and helping to harvest energy and increase host fat storage [88].”
- Colonocyte metabolism shapes the gut microbiota (2018, background): “Dysbiosis in the colon is commonly associated with an increased abundance of facultative anaerobic bacteria (28, 29), which is observed in individuals undergoing antibiotic therapy (30), consuming a high-fat Western-style diet (31, 32), or suffering from inflammatory bowel disease (33), colorectal c”