Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish
By I. Semova, J. Carten, Jesse Stombaugh, L. Mackey, Rob Knight, S. Farber, J. Rawls. Cell Host and Microbe, 2012
812 citations recorded by the source corpus.
SUMMARY Regulation of intestinal dietary fat absorption is critical to maintaining energy balance. While intestinal microbiota clearly impact the host’s energy balance, their role in intestinal absorption and extra-intestinal metabolism of dietary fat is less clear. Using in vivo imaging of fluorescent fatty acid (FA) analogs delivered to gnotobiotic zebrafish hosts, we reveal that microbiota stimulate FA uptake and lipid droplet (LD) formation in the intestinal epithelium and liver. Microbiota increase epithelial LD number in a diet-dependent manner. The presence of food led to the intestinal enrichment of bacteria from the phylum Firmicutes. Diet-enriched Firmicutes and their products were sufficient to increase epithelial LD number, whereas LD size was increased by other bacterial types. Thus, different members of the intestinal microbiota promote FA absorption via distinct mechanisms. Diet-induced alterations in microbiota composition might influence fat absorption, providing mechanistic insight into how microbiota-diet interactions regulate host energy balance.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/7112c1bc5eb17192583b97a46da1df0b0861efe1
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In Molecular Biology
Citations in the corpus
- Bacterial symbiosis in the fish gut and its role in health and metabolism (2017, background): “In a study, Semova et al. (2014) have confirmed the involvement of microbiota in intestinal absorption of nutrient and metabolism of fatty acid in Zebra fish (Danio rerio).”
- Effect of dietary bile acids on growth, body composition, lipid metabolism and microbiota in grass carp (Ctenopharyngodon idella) (2018, background): “In addition, it is well established that lipid metabolism affects intestinal microbiota (Semova et al., 2012; Tremaroli & Bäckhed, 2012; Velagapudi et al., 2010).”
- The development of the gut microbiota in rainbow trout (Oncorhynchus mykiss) is affected by first feeding and diet type (2014, background): “There is currently a growing focus on gut microbiota in relation to its influence on parameters such as health status, metabolism and generally a wide range of biological processes (Semova et al., 2012; Navarrete et al., 2012; Rawls et al., 2004).”