Induction of vanilloid receptor channel activity by protein kinase C

By L. Premkumar, G. Ahern. Nature, 2000

847 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/624856f1b8cdb38104e3bcb602455c7f4c6bc201

How researchers see this paper

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In Molecular Biology

1. D. Julius
2. D. Clapham
3. A. Basbaum
4. B. Nilius
5. G. Owsianik
6. D. McKemy
7. H. Chuang
8. D. Bautista

In Physiology

1. D. Julius
2. S. Jordt
3. D. Bautista
4. G. Owsianik
5. A. Basbaum
6. B. Nilius
7. R. Ross
8. Arne May

In Sensory Systems

1. D. Julius
2. B. Nilius
3. D. Clapham
4. D. Bautista
5. G. Owsianik
6. A. Basbaum
7. S. Jordt
8. R. Ross

Citations in the corpus

• Molecular mechanisms of nociception (2001, background): “, an effect that may be mediated through direct or indirect modification of VR1 by the e-isoform of PK”
• TRP channels and pain. (2013, background): “…of TRPV1 at two main intracellular sites (S502 and S800) located within the loop connecting TM3 and TM4 and the proximal region of the C-terminal tail, respectively (Bhave et al. 2003, Cesare & McNaughton 1996, Numazaki et al. 2002, Premkumar & Ahern 2000, Vellani et al. 2001) (Figure 4a).”
• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “Genetic and electrophysiological studies suggest that bradykinin-evoked thermal hypersensitivity is produced through PLC-mediated potentiation of TRPV1 (Cesare et al., 1999; Chuang et al., 2001; Premkumar and Ahern, 2000).”
• The transient receptor potential family of ion channels (2011, background): “PKC­dependent phosphorylation might be a direct activatory mechanism or might sensitize the channel for other stimuli (for example, it sensitizes TRPV1 to heat or capsaicin) [73,74].”
• Anandamide and vanilloid TRPV1 receptors (2003, background): “Premkumar & Ahern (2000) report that the repeated application of anandamide evokes progressively larger TRPV1 currents in oocytes and that anandamide treatment enhances proton-evoked currents.”
• NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels (2005, background): “This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicingated ion channel, TRPV1.”
• An introduction to TRP channels. (2006, background): “0 antagonist (56, 75, 126) I HEK, SCG 2-APB TRPV1 114-249μM 1.”
• Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition (2001, background): “, and that PKC potentiates capsaicin-evoked responses in VR1-expressing oocyte”
• Identification of a cold receptor reveals a general role for TRP channels in thermosensation (2002, background): “Indeed, several TRP channels are regulated by receptors that couple to phospholipase C (PLC), and the thermal activation threshold for VR1 can be markedly shifted to lower temperatures by inflammatory agents (for example, bradykinin and nerve growth factor) that activate this pathwa”