Molecular mechanisms of nociception

By D. Julius, A. Basbaum. Nature, 2001

2,626 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/b8a1d0395356ba866d980fad86f71e5f9b76c86d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Arne May
2. Clifford J. Woolf
3. D. Julius
4. Ardem Patapoutian
5. R. Medzhitov
6. D. Bautista
7. B. Nilius
8. H. Fields

In Physiology

1. Arne May
2. Clifford J. Woolf
3. Marwan N. Baliki
4. D. Julius
5. R. Medzhitov
6. Irene Tracey
7. Ardem Patapoutian
8. S. Jordt

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. B. Nilius
5. D. Bautista
6. Arne May
7. R. Medzhitov
8. A. Basbaum

Citations in the corpus

• Stress, Inflammation, and Defense of Homeostasis (2014, background): “C-fiber nociceptors locally produce CGRP and Substance P upon activation by these stressors, and these neuropeptides coordinate local stress adaptations known as neuro-inflammation (Julius and Basbaum, 2001).”
• Identification of a cold receptor reveals a general role for TRP channels in thermosensation (2002, background): “These primary afferent neurons convert thermal stimuli into electrochemical signals (that is, action potentials) and relay sensory information to integrative centres in the spinal cord and brai”
• Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. (2002, background): “Other recent reviews cover relevant aspects of ENaC/DEG family members in more detail than this review: amiloride-sensitive channels in epithelia (87), molecular mechanisms of human hypertension (153, 209), taste reception (155, 156), nociception (131, 175, 269), touch sensation in C.”
• Origin and physiological roles of inflammation (2008, background): “ATP also activates nociceptors (which are sensory receptors), thereby reporting tissue injury to the nervous syste”
• State-dependent opioid control of pain (2004, background): “We now know a great deal about the molecular mechanisms of transduction and the relationship of the firing of these neurons to stimulus intensity and to the psychophysics of perceived pain intensit”
• Transient receptor potential channels: targeting pain at the source (2009, background): “The specificity of putative TRPV1 actions beyond primary sensory neurons, where its expression levels are by far the highes”