Gut feelings: the emerging biology of gut–brain communication

By Emeran A. Mayer. Nature Reviews Neuroscience, 2011

1,548 citations recorded by the source corpus.

The concept that the gut and the brain are closely connected, and that this interaction plays an important part not only in gastrointestinal function but also in certain feeling states and in intuitive decision making, is deeply rooted in our language. Recent neurobiological insights into this gut–brain crosstalk have revealed a complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making. Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders.

Subfields: Gastroenterology, Pharmacy, Social Psychology

View Paper: https://www.semanticscholar.org/paper/c3e26b9bfec3a313f48f1815e991934ebe53fab0

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Citations in the corpus

Gut Microbes and the Brain: Paradigm Shift in Neuroscience (2014, background): “Although gutbrain interactions have been studied for decades, providing a wealth of information about the close interactions between the gut-associated immune system, enteric nervous system, and gutbased endocrine system (Mayer, 2011), these findings have largely been ignored by the psychiatric and ”
A Neural Circuit for Gut-Induced Reward. (2018, neutral): “These include anxiety, depression, cognition, and reinforcement (Bohorquez and Liddle, 2015; Clemmensen et al., 2017; de Araujo et al., 2012; Mayer, 2011; Sharon et al., 2016).”
Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine (2014, neutral): “Thesefindingsare especially interesting in light of the critical role serotonin plays as a signaling molecule in the enteric nervous system (Mayer, 2011; Ormsbee and Fondacaro, 1985), where modulation of the serotonin receptors has been proposed as a treatment for irritable bowel syndrome (Gershon a”
A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. (2015, background): “release immune activating and other signaling molecules that may play an important role in regulating the brain and subsequent behavior (Mayer, 2011; Cryan and Dinan, 2012; Foster and McVey Neufeld, 2013).”
Heart Rate Variability (HRV) Analysis: A Methodology for Organizational Neuroscience (2019, background): “Together with the sympathetic and parasympathetic, a separate component of the ANS is the enteric nervous system (ENS), the intrinsic nervous system of the gastrointestinal tract (for a review, see Mayer, 2011).”
Current understanding of dysbiosis in disease in human and animal models (2016, background): “Autism Spectrum Disorders Autism spectrum disorders (ASD), are a group of disorders that include autism and Asperger’s syndrome that are characterized by social and communication deficits, repetitive behaviors, and sometimes, cognitive delays.(35) The exact cause of ASD is still largely unknown; how”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…intestinal organs and was first introduced in terms of peripheral regulation of emotions by William James and Carl Lange in the 1880s and further challenged and refined by Walter Cannon in the 1920s to account for the primacy of the brain in regulating gastrointestinal function (see Mayer 2011).”
Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation (2013, background): “This communication system is called the gut–brain axis, which consists of intricate loops of neurological reflexes [Mayer, 2011].”