The mechanism and regulation of chromosomal V(D)J recombination.

By C. Bassing, W. Swat, F. Alt. Cell, 2002

988 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/61823a4c691165f49501f75c3f28d14e23491b55

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In Immunology

Citations in the corpus

T cell– and B cell–independent adaptive immunity mediated by natural killer cells (2006, background): “Specialized contributions by a(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.”
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair (2004, methodology): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5897">RAG2 endonuclease complex and is completed by components of the NON-HOMOLOGOUS END-JOINING (NHEJ) machiner”
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. (2006, neutral): “The lymphoid-specific recombination activating gene (RAG) 1 and 2 encoded endonuclease initiates the reaction by introducing a DSB at recombination-specific sequences (RSS) that flank all V, D, and J gene units (Bassing et al., 2002).”
Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, positive): “See text for details. cally would permit direct V to J joins based simply enhancer could provide V(D)J recombinational accessibility in vivo (Ferrier et al., 1990; Lauzurica and Krangel,on the 12/23 rule (Bassing et al., 2002), but such joins rarely occur.”
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. (2006, background): “Variable regions of antigen receptors, including IgH and IgL chains and TCR chains, are assembled from germline V, D, and J gene segments through a site-specific recombination reaction known as V(D)J recombination (2, 3).”
Naïve Human Antibody Libraries for Infectious Diseases (2018, background): “These flanking DNA sequences are known as RSS which are conserved heptamer and nanomer sequences separated by a spacer which is either 12 or 23 bp in length [4, 19].”
Transcription-targeted DNA deamination by the AID antibody diversification enzyme (2003, background): “Immunoglobulin heavy (IgH) and light (IgL) chain variable region exons are assembled in developing B-lineage cells by recombination of V, D and J segments—V(D)J recombinatio”
Antibody modeling using the Prediction of ImmunoGlobulin Structure (PIGS) web server (2014, background): “They have the ability to recognize virtually any foreign molecule with exquisite specificity and very high affinity 1–3 .”
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells (2020, neutral): “Due to VDJ recombination and somatic hypermutation, B cells exhibit diverse B cell repertoires, necessitating the analysis of one B cell at a time (Bassing et al., 2002).”
Deep generative models for T cell receptor protein sequences (2019, background): “For detailed reviews of V(D)J recombination see Bassing et al. (2002) , and Schatz and Ji (2011) .”
Regulation and mechanisms of mammalian double-strand break repair (2003, background): “…forks when the replication machinery encounters single-stranded breaks (SSBs) in the template DNA, and programmed cleavage by specific endonucleases during meiotic recombination and immunoglobulin gene rearrangement (Haber, 2000; Karran, 2000; Norbury and Hickson, 2001; Bassing et al., 2002b).”
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL (2002, background): “Early B cell precursors generate antigen recognition diversity by assembling immunoglobulin (Ig) variable-region V(D)J exons from individual variable (V), diversity (D) and joining (J) gene segments through recombination-activating gene 1 (RAG-1) and RAG-2 protein”