Transcription-targeted DNA deamination by the AID antibody diversification enzyme

By J. Chaudhuri, Ming Tian, C. Khuong, Katrin F. Chua, E. Pinaud, F. Alt. Nature, 2003

788 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ded4c946bf96a18a71bea59eb615d3be1fc713b

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Citations in the corpus

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation (2003, background): “Purified AID catalyses the deamination of C to U on single-stranded (ss)DN”
Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation (2019, background): “Apart from ssDNA targets, the AID enzyme is also able to deaminate dsDNA in vitro in a transcriptional-oriented manner; hence, it is useful for gene diversification [195,196].”
Induction of activation‐induced cytidine deaminase gene expression by IL‐4 and CD40 ligation is dependent on STAT6 and NFκB (2004, methodology): “CD40 ligation also synergized with IL-4 to induce strong AID mRNA and protein expression in mouse primary B cells (8, 19 ).”
Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, neutral): “Expression of the RAG proteins in developing B and T lineage cells occurs in nonproliferating cells.tion catalyzed by AID (Chaudhuri et al., 2003; Ramiro et al., 2003).”
Mechanism and regulation of class switch recombination. (2008, background): “AID co-immunoprecipitates with RNA polymerase II in splenic B cells undergoing CSR (195).”
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. (2006, background): “The AID (activation-induced deaminase) enzyme is required for this process (123), and deaminates cytidine residues in single-stranded DNA generated within S regions undergoing transcription (124).”
Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, positive): “Because AID mediates CSR and somatic hypermutation (SHM) by initiating deamination of bases of single-stranded nontemplate DNA during transcription ( Chaudhuri et al., 2003 ), we investigated whether recruitment of AID is essential for the generation of DSBs by monitoring the enrichment of Ku80 at t”
DNA deamination mediates innate immunity to retroviral infection. (2003, background): “Chaudhuri et al., 2003) and APOBEC1 (Figure 1A, lane How Vif mediates HIV infectivity is not yet known and 1 and Petersen-Mahrt and Neuberger, 2003). few clues are apparent in its amino acid sequence as it is highly variable amongst HIV isolates and shows little MLV Produced in CEM15/APOBEC3G Cells…”
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters (2012, positive): “, 2010), requires ssDNA substrates and targets transcribed loci, including R loop-forming regions (Chaudhuri et al., 2003; Pham et al., 2003; Yu et al., 2005).”