DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

By Mikhail B. Litinskiy, B. Nardelli, D. Hilbert, B. He, A. Schaffer, P. Casali, A. Cerutti. Nature Immunology, 2002

1,379 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/39ea8ce159ac97a86a531ba545586ee18aed970b

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Citations in the corpus

Dendritic cells: translating innate to adaptive immunity. (2006, background): “In other studies, DCs are able to induce class switching on B cells in the presence [204] or absence [205] of CD40 ligation, the latter through BLys and April TNF family members.”
The regulation of IgA class switching (2008, background): “During this process, DCs release soluble class-switch-inducing factors related to CD40L, including B-cell activating factor ( BAFF ; also known as BLyS) and a proliferation-inducing ligand ( APRIL”
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans (2005, background): “Functional studies propose a role for APRIL in T cell–independent class switch recombination (CSR”
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. (2003, background): “…and virus stimulation of 4 104 pDCs during 48 hr (one of three experiments). ate into plasma blasts while pDC-derived IL-6 permits BLyS and APRIL, support this hypothesis (Balazs et al., 2002; Litinskiy et al., 2002; MacLennan and Vinuesa,plasma blasts to become antibody-secreting plasma cells.”
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 (2008, background): “Nevertheless, although published work has suggested the involvement of DCs in gut IgA productio”
TACI is mutant in common variable immunodeficiency and IgA deficiency (2005, background): “This class switch recombination requires two signals: one signal is normally delivered by cytokines, and the second signal is normally delivered by select members of the tumor necrosis factor receptor family expressed on B cells that include CD40, TACI and BAFF-R (B cell–activating factor of the tum”
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “…of mDCs that can directly act on the growth and differentiation of B cells (Dubois et al., 1997; Garcia De Vinuesa et al., 1999). mDCs trigger B cell growth and differentiation through IL-12 and IL-6 (Dubois et al., 1998) as well as B cell-activating factor (BAFF) (Litinskiy et al., 2002).”
IgA response to symbiotic bacteria as a mediator of gut homeostasis. (2007, background): “The result of locally controlled IgA produc- tion is to create a simple feedback loop that bypasses the systemic immune system: i.e., where DCs, and epithelial cells drive IgA production independent of T cells until suf- ficient levels of IgA block microbial stimulation.”
Induction of activation‐induced cytidine deaminase gene expression by IL‐4 and CD40 ligation is dependent on STAT6 and NFκB (2004, background): “However, p52 is activated by BAFF, which was recently shown to induce AID and activate CSR ( 14 ), and may play a role in the induction of AID by BAFF.”
Shared and Distinct Functions of Type I and Type III Interferons (2019, neutral): “…IFNAR expression on intestinal epithelial cells, which are targets for enteric viruses including norovirus, reovirus, rotavirus, and enteroviruses (Baldridge et al., 2017; Good et al., 2019; Johansson et al., 2007; Lin et al., 2016; Mahlakõiv et al., 2015; Nice et al., 2015; Pott et al., 2011).”