Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.

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MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings (2008, background): “On the one hand, DSBs are necessary for such vital processes as meiotic recombination [1] and vertebrate immune system development [ 2 ].”
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway (2010, background): “to form a signal joint is also reliant on Ku and the ligase IV complex, but joining is not dependent on Artemis or DNA-PKcs (65, 137).”
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. (2008, unknown): “The random nature of V(D)J recombination and the multiplicity of the Ig loci, required for the generation of a diverse antibody repertoire, call for sophisticated mechanisms to guarantee that the differentiating B cells are able to express surface Ig and that this Ig consists of a single molecular s”
Development and selection of γδ T cells (2007, result): “However, other studies indicate that even in the adult stage, newly generated B cells show a bias for rearrangement of 3#-VH gene segments (42, 43).”
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. (2008, unknown): “In addition, the rearrangements of the IgH locus are sequential with DH to JH joining occurring on both alleles prior to VH to DHJH segment rearrangement (Jung et al., 2006).”