Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
By J. Chaudhuri, F. Alt. Nature reviews. Immunology, 2004
621 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/69d8906922b21c92801be5c462f04d71d1a3f331
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- David H. Jung
- A. Cerutti
- A. Aguilera
- R. Mostoslavsky
- Cosmas C. Giallourakis
- K. Rajewsky
- Christopher K. Glass
- F. Alt
In Molecular Biology
- Christopher K. Glass
- A. Cerutti
- Tatiana García-Muse
- A. Aguilera
- Changchun Xiao
- R. Mostoslavsky
- Michael G. Rosenfeld
- David H. Jung
Citations in the corpus
- R loops: from transcription byproducts to threats to genome stability. (2012, background): “…abolishes CSR. Inverting the S region, therefore making the displaced ssDNA the low G content strand, or reducing the global G content of the S region, decreases CSR dramatically (Chaudhuri and Alt, 2004) consistent with the relevance of G clusters in R loop stabilization (Roy and Lieber, 2009).”
- MicroRNA control in the immune system: basic principles. (2009, background): “of this miRNA is the enzyme AID, a central player in the germinal center reaction, mediating class switch recombination (CSR) and somatic hypermutation (SHM) (Chaudhuri and Alt, 2004; Di Noia and Neuberger, 2007; Honjo et al., 2004).”
- Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, positive): “However, precedents such as gross chromosomal rearrangements (GCRs) in yeast (Myung et al., 2001), V(D)J recombination, and class switch recombination (CSR) during T and B cell development ( Chaudhuri and Alt, 2004 ) argue for a role of genetically based and cell lineage-specific juxtaposition of tr”
- Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. (2006, background): “The deaminated cytidines eventually yield strand lesions that may ultimately lead to DSBs by mechanisms that are still under intense investigation (125).”
- The regulation of IgA class switching (2008, background): “Class switching substitutes the IgH constant region μ (C μ ) and C δ genes encoding primary IgM and IgD isotypes with C γ , C α or C e genes through a process known as class-switch recombination (CSR”