Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

By Paul Jorgensen, Joy L. Nishikawa, Bobby-Joe Breitkreutz, Mike Tyers. Science, 2002

851 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/616b7583818ca495890872e562329e6b3d396b6f

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In Molecular Biology

Citations in the corpus

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “One of the main TORC1-regulated roles of Sch9 is to modulate translation and cell size attained before cell division (Jorgensen et al., 2002, 2004).”
Ribosomal proteins: functions beyond the ribosome. (2015, background): “…study that analyzes the complete set of yeast strains with deletion of each of the 6000 yeast genes reveals that depletion of Sfp1, a transcription factor important for controlling expression of over 60 genes involved in ribosome assembly, results in the smallest cell size (Jorgensen et al., 2002).”
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “TOR is indeed dedicated to controlling cell growth, but what is this target and how does it control cell growth?”
Integrative analysis of cell cycle control in budding yeast. (2004, background): “Viable, grows slowly, reduced size at birth, reduced size at budding (Jorgensen et al., 2002; Wasch and Cross, 2002) Viable, normal growth rate, small at birth, normal size at budding Cdh1 promotes proteolysis of some activator of start?”
How cells coordinate growth and division. (2004, background): “Despite having stable average volumes that differ over a two-fold range, whi5∆, cln3∆, and wild-type cells have about the same doubling time in glucose media [68,69,78].”
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. (2005, background): “…in a W303 background strain (see below). s tWhile the reason for this difference is unknown, the fact that S288C pih1D deletion mutants exhibit a small cell s usize (whi) phenotype (Jorgensen et al., 2002) suggests an important role for this protein in cell growth and/ a por division.”
Influence of Metabolism on Epigenetics and Disease (2013, neutral): “of yeast cells into the cell division cycle (Jorgensen et al., 2002).”
Current approaches to gene regulatory network modelling (2007, background): “For instance, cell growth can be decoupled from cell cycle in yeast (e.g., [112]), indicating that to some extent independent modules control these two processes.”
From genomics to proteomics (2003, background): “Independent systematic analysis of yeast-cell size mutants (phenomics) and the gene set regulated by one of these size-control genes (transcriptomics) revealed an unanticipated regulatory relationship between ribosome biogenesis and commitment to cell divisio”
Nutritional Control of Growth and Development in Yeast (2012, background): “74 J. R. Broach D ow nloaded from https://academ ic.oup.com /genetics/article/192/1/73/5935009 by guest on 04 M arch 2022”
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. (2004, methodology): “It has recently been discovered that SBF, and likely MBF, activation occurs upon dissociation of the Start-repressor Whi5 (Jorgensen et al. 2002; Costanzo et al. 2004; de Bruin et al. 2004).”
Mapping pathways and phenotypes by systematic gene overexpression. (2006, methodology): “To classify the overexpression phenotypes as gain-or loss-of-function, we compared them to deletion phenotype information derived from large-scale characterizations (Giaever et al., 2002; Jorgensen et al., 2002; Mnaimneh et al., 2004; Saito et al., 2004) and the literature (Table S9).”