Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
By R. Loewith, Michael N. Hall. Genetics, 2011
883 citations recorded by the source corpus.
TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/8a2eb47ae0a003a2a42e2380de91792593d606d4
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In Molecular Biology
- R. A. Saxton
- Marta Rubio‐Texeira
- David M. Sabatini
- M. Conrad
- J. Schothorst
- J. Thevelein
- G. Van Zeebroeck
- H. Kankipati
In Pharmacology
Citations in the corpus
- mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “Like mammals, S. cerevisiae also have two distinct TOR containing complexes, TORC1 and TORC2 (reviewed in Loewith and Hall, 2011) as well as homologs of Raptor (Kog1), mLST8 (Lst8), Rictor (Avo3), and mSin1 (Avo1), although several additional components are yeast or mammal specific.”
- Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, methodology): “The FRB domain is responsible for binding to FKBP (FK506 binding protein)-rapamycin (Loewith & Hall, 2011).”
- mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “Like mammals, S. cerevisiae also have two distinct TOR containing complexes, TORC1 and TORC2 (reviewed in Loewith and Hall, 2011) aswell as homologs of Raptor (Kog1), mLST8 (Lst8), Rictor (Avo3), and mSin1 (Avo1), although several additional components are yeast or mammal specific.”
- Nutrient sensing and TOR signaling in yeast and mammals (2017, neutral): “…anabolic processes such as protein, lipid, and nucleotide synthesis, and represses catabolic processes such as autophagy, to ultimately promote cell growth (for review, see Wullschleger et al , 2006; Loewith & Hall, 2011; Howell et al , 2013; Laplante & Sabatini, 2013; Shimobayashi & Hall, 2014).”