Influence of Metabolism on Epigenetics and Disease

By W. Kaelin, S. McKnight. Cell, 2013

854 citations recorded by the source corpus.

Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/732b8265382027a841509c4b7ef3185231cba71c

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Citations in the corpus

Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences (2015, background): “It has become evident that metabolites themselves must feed back to regulate gene expression, signal transduction, and various protein activities in cellular decision-making processes [1,2].”
Understanding the intersections between metabolism and cancer biology (2017, neutral): “In all cases, an accumulated metabolite inhibits enzymes using αKG as a co-substrate to promote tumorigenesis (Kaelin and McKnight, 2013).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “In addition to isocitrate, other amino acids, such as arginine, histidine, proline, and glutamate from glutamine-derived glutaminolysis also mediate αKG synthesis (Wise et al., 2011; Metallo et al., 2012; Mullen et al., 2012; Kaelin and McKnight, 2013).”
T cell metabolism drives immunity (2015, background): “We are just beginning to understand the many connections between metabolism and gene regulation in T cells (Lu and Thompson, 2012; Wang and Green, 2012; Kaelin and McKnight, 2013; Öst and Pospisilik, 2015).”
The world of protein acetylation. (2016, background): “If so, they are regulated differently than most kinases, which have activities independent of the concentration of their cofactor ATP [324,325].”
Fundamentals of cancer metabolism (2016, background): “Several othermetabolites, including acetyl-CoA, a-ketoglutarate, and S-adenosylmethionine also participate in epigenetic reprogramming, and timewill tell whether genetically specific alterations of thesemetabolites in tumors promote tumorigenesis (54).”