Mapping pathways and phenotypes by systematic gene overexpression.

By Richelle Sopko, Dongqing Huang, Nicolle Preston, Gordon Chua, Balázs Papp, Kimberly A. Kafadar, Michael Snyder, S. Oliver, M. Cyert, Timothy R. Hughes and 2 more. Molecules and Cells, 2006

684 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3cb1577d39f462c7f496ea2538b5fbd5292cf12b

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In Molecular Biology

1. Miguel Andrade
2. Charles Boone
3. Brenda J. Andrews
4. Ulrich Stelzl
5. H. Bussey
6. D. E. Levin

Citations in the corpus

• A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, background): “In a genome-wide screen in yeast, overproduction of 15% of proteins resulted in a growth defect, and only 3.5% of the proteins produced morphological changes associated with this phenotype ( 57 ).”
• Genetic reconstruction of a functional transcriptional regulatory network (2007, methodology): “To investigate further, we used HSF1 as an example and profiled expression changes after overexpressing HSF1 (ref”
• Exploring genetic interactions and networks with yeast (2007, background): “In addition to examining loss-of-function phenotypes associated with deletion-mutant alleles, overexpression alleles enable the exploration of gain-of-function phenotypes to augment gene-function analysi”