How cells coordinate growth and division.

By Paul Jorgensen, Mike Tyers. Current Biology, 2004

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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “In proliferating cells, cell growth is coordinated with the cell division cycle to ensure that on average each cell division is accompanied by a doubling in mass in order to maintain cell size (Jorgensen and Tyers, 2004).”
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation (2011, background): “Consequently, one of the fundamental problems in animal cells is coordination of the metabolic program with cell growth- and proliferation-associated bioenergetic demand (Jorgensen and Tyers, 2004).”
Mechanisms and pathways of growth failure in primordial dwarfism. (2011, background): “In yeast, it is well established that there is a ‘‘restriction point’’ where cells halt progress in G1 or G2 if they have not grown to a minimum size (Hartwell et al. 1974; Nurse 1975; Jorgensen and Tyers 2004).”