LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

By J. Lizcano, Olga Göransson, R. Toth, M. Deák, N. Morrice, J. Boudeau, S. Hawley, Lina Udd, T. Mäkelä, D. Hardie and 1 more. EMBO Journal, 2004

1,432 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/5ffeee9a37db4c38547358cf3b71f12788d13b3a

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Citations in the corpus

Fuel feeds function: energy metabolism and the T-cell response (2005, background): “AMPK is activated allosterically by increasing concentrations of cellular AMP and by the subsequent STK11 (serine/threonine kinase 11)-dependent phosphorylation of its catalytic subunit, the α-subuni”
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, neutral): “Recently, it was shown that LKB1 can activate 11 AMPK-related kinases by phosphorylation of a threonine residue equivalent to Thr172 in AMPK (Lizcano et al., 2004).”
AMPK in Health and Disease. (2009, background): “For ionomycin-dependent activation of AMPK in the absence of LKB1, the total activation was maintained and 90% in inhibited by STO-609; this is consistent with CaMKK being responsible (550).”
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “This might initially appear surprising, but LKB1 is also required for the activity of 12 kinases of the AMPK-related kinase family in addition to AMPK, being responsible for phosphorylation of the threonine residues equivalent to Thr 172 in all of them (Lizcano et al. 2004).”
The LKB1-AMPK pathway: metabolism and growth control in tumor suppression (2009, background): “LKB1 also phosphorylates and activates 12 kinases that are closely related to AMP”
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. (2004, background): “It should be noted that, in addition to AMPK, LKB1 can phosphorylate and activate several AMPK-related kinases—although these kinases are not regulated by AMP (Lizcano et al. 2004).”
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis (2007, background): “The energy-sensing LKB1–AMPK pathway regulates cell survival under conditions of nutrient and energy-deprivation that increase AMP:ATP ratio”