AMPK in Health and Disease.

By G. Steinberg, Bruce E. Kemp. Physiological Reviews, 2009

1,692 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/355f6874d42c841e806b7965904f455dfccebe7c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. R. Scarpulla
2. Y. Lei
3. M. Huang
4. Lu Zhang
5. Sushmita Jha
6. Bruce E. Kemp
7. Denis Gris
8. Haitao Wen

In Molecular Biology

1. R. Scarpulla
2. Bruce E. Kemp
3. G. Thomas
4. Haitao Wen
5. B. Viollet
6. N. Bardeesy
7. A. Hevener
8. S. Kozma

In Surgery

1. R. Scarpulla
2. Bruce E. Kemp
3. B. Viollet
4. A. Hevener
5. D. Hardie

Citations in the corpus

• AMPK, insulin resistance, and the metabolic syndrome. (2013, neutral): “Others have not observed such effects, however (6, 22, 150).”
• AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan (2011, background): “, 5aminoimidazole-4-carboxamide riboside (AICAR), metformin, statins, thiazolidinediones, and several natural plant products [2, 5, 6].”
• The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (2015, positive): “A well-described role of AICAR is to activate AMPK and stimulate fatty acid oxidation via phosphorylation-induced inactivation of acetyl-CoA carboxylase (ACC) that consequently alleviates allosteric inhibition of carnitine palmitoyltransferase 1 (CPT-1), and also enhance glucose uptake in muscle (St”
• Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “Similarly, AMP-activated protein kinase (AMPK), an enzyme sensor that is activated upon energy depletion in muscle [66], phosphorylates PGC-1α on specific serine and threonine residues.”
• Fatty acid-induced NLRP3-PYCARD inflammasome activation interferes with insulin signaling (2011, positive): “The AMP-activated protein kinase (AMPK) has emerged as an essential mediator of fatty acid metabolis”
• Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner (2010, background): “However, inhibition of glycolytic flux also leads to increased intracellular AMP levels and activation of AMP-activated kinase (AMPK) (Hardie, 2008; Steinberg and Kemp, 2009).”