Fuel feeds function: energy metabolism and the T-cell response

By C. Fox, P. Hammerman, Craig B. Thompson. Nature reviews. Immunology, 2005

876 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6eb38f390cfc69597bfbf84f6fc20f4c687e636e

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Citations in the corpus

The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, background): “Themetabolic shift in tumors toward glycolysis occurs not only in the cancer cells but also in T lymphocytes during their activation (69).”
Resilience in farm animals: biology, management, breeding and implications for animal welfare (2016, background): “Importantly, the nutrient economy of the cell is not managed autonomously by the cell but is regulated via extracellular signals received predominantly via chemosensors (Fox et al. 2005).”
Sleep and immune function (2011, background): “(5) The endocrine and autonomous nervous systems regulate immune functions not only directly via hormones and neural innervation, but also indirectly via influences on blood flow, blood pressure, lymph flow [80, 90], the supply of substrates like glucose, fatty acids and oxygen [5, 44, 114] and on n”
Posttranscriptional control of T cell effector function by aerobic glycolysis. (2013, positive): “…T cells and cancer cells engage glycolysis, where pyruvate is fermented to lactate in the cytoplasm even when sufficient oxygen is present to utilize OXPHOS, a process termed the Warburg effect (Fox et al., 2005; Frauwirth et al., 2002; Gerriets and Rathmell, 2012; Jones and Thompson, 2007).”
LXR signaling couples sterol metabolism to proliferation in the acquired immune response (2008, background): “For example, activated T lymphocytes are functionally glycolytic despite sufficient oxygen tension (Fox et al., 2005).”
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 (2008, background): “Although some regulation of cellular metabolism is anapleurotic and is met by enhanced flux due to relief of feedback inhibition in pathways whose end products are rapidly used, it has become increasingly apparent that regulatory mechanisms also exist to promote specific metabolic pathways and pheno”
PD-1 signaling in primary T cells (2009, background): “We and many others have shown that the main targets of negative regulators of T-cell activation are cell growth and metabolism (13, 15, 39, 83).”
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells (2015, background): “Notably, the much smaller set of genes with significant correlation patterns after correction was enriched for genes involved in glycolysis 34 and for genes that mark the cellular response to IL-4 stimulation ( Supplementary Table 3a ), both of which are key processes in T H 2 cell differentiation.”
Metabolic Pathways In Immune Cell Activation And Quiescence (2013, background): “These attributes of activated T cells have led to their ‘‘metabolic’’ comparison with tumor cells, given that both cell types have been shown to engage Warburg metabolism when proliferating (Fox et al., 2005; Jones and Thompson, 2007; van Bruggen et al., 2010; Vander Heiden et al., 2009) (in contras”
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “Importantly, although the data showing that memory T and Tn cells acquire more 2- NBDG than Teff are surprising, they do not argue against a role for glucose and glycolysis in Teff cell proliferation or effector function (Chang et al., 2013; Fox et al., 2005; Jacobs et al., 2008; Wang et al., 2011).”