A microbial symbiosis factor prevents intestinal inflammatory disease

By S. Mazmanian, June L. Round, D. Kasper. Nature, 2008

2,372 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/5e63430a7fd99034e96eb1fb97730aca8f36af2c

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Citations in the corpus

Genetics and pathogenesis of inflammatory bowel disease (2011, background): “The common constituent of normal human microflora Bacteroides fragilis produces polysaccharide A, which suppresses IL-17 production and promotes the activity of IL-10-producing CD4 + T cells in mic”
Principles and clinical implications of the brain–gut–enteric microbiota axis (2009, neutral): “The human gut harbors 400–1,000 different bacterial species”
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis (2010, background): “We have recently shown that symbiotic intestinal bacterial molecules direct the development of the mammalian immune system and confer protection from intestinal disease (15, 27); thus, fundamental aspects of mammalian health are absolutely dependent on microbial symbiosis.”
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells (2010, background): “…defective T and B cell compartments in gut-associated lymphoid tissue, reduced complements of immunoglobulin G (IgG) and IgA antibodies (Abs), etc. (Mazmanian et al., 2005, 2008; Rakoff-Nahoum et al., 2004; Ivanov et al., 2008; Atarashi et al., 2008; Grice et al., 2009; Macpherson and Harris,…”
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (2011, neutral): “This indicates that both elements of the microbiota and detection mechanisms are required for maintaining a healthy epithelial barrier (Mazmanian et al., 2008).”
What are the consequences of the disappearing human microbiota? (2009, background): “Are these organisms pathogens, or should they be considered to be members of the indigenous microbiota that have evolved to live in perilous location”
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease (2015, background): “fragilis-derived polysaccharide A, have previously been demonstrated to have immunomodulatory functions [47] [48] [49].”
The Microbiome in Infectious Disease and Inflammation (2012, neutral): “hepaticus or trinitrobenzene sulfonic acid in the intestine (251).”
Defining dysbiosis and its influence on host immunity and disease (2014, background): “…back to a healthy state A handful of studies have now demonstrated that replacement of beneficial bacterial species can protect and even cure diseases in animal model systems and human patients (Mazmanian et al., 2008; Sokol et al., 2008; Ochoa-Reparaz et al., 2010; Round and Mazmanian, 2010).”
From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome (2012, background): “Similarly, there is a dearth of empirical data indicating whether people with high or low diversity microbiomes are more prone or resistant to disease, although there is some evidence suggesting that such relationships may exist (Chang et al. 2008, Mazmanian et al. 2008, Packey & Sartor 2009).”