Genetics and pathogenesis of inflammatory bowel disease

By B. Khor, A. Gardet, Ramnik J. Xavier. Nature, 2011

1,594 citations recorded by the source corpus.

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host–commensal relationship.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/866bfb52700febaa232c3285dbb6e7a9ffdb0f1c

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Citations in the corpus

How informative is the mouse for human gut microbiota research? (2015, background): “Inflammatory bowel disease The development of IBD has been linked to genetic factors, infectious pathogens and alterations in the composition of the gut microbiota (Jostins et al., 2012; Khor et al., 2011), even though the respective causal importance of these factors still awaits clarification.”
The treatment-naive microbiome in new-onset Crohn's disease. (2014, background): “Studies of the intestinal gut microbiota imply that an unbalanced microbial community composition is associated with a dysregulated immune response (Khor et al., 2011).”
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, background): “org 10 fundamental role in IBD; gut microbiota with its specific genetic makeup and environmental factors have significant contributions in IBD pathogenesis (127, 128).”
Discovering biomarkers associated and predicting cardiovascular disease with high accuracy using a novel nexus of machine learning techniques for precision medicine (2023, background): “diseases including but not limited to Crohn’s disease [19], inflammatory bowel disease [20], breast cancer [21], colon cancer [22] and Alzheimer's disease [23].”
A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “NOD2 has also been implicated in the initiation of autophagy [8, 22].”
The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “The majority of these are genes related to immune homeostasis in the intestine such as MUC19, involved in gut barrier function, CARD9 (mucosal defense), CCL8 and IL8R (innate cell recruitment), IL23R (mucosal T cell responses), and NOD2, an associated gene involved in bacterial sensing (170).”
Mechanisms of Disease: Inflammatory Bowel Diseases. (2019, background): “Acknowledgments: KA Papadakis is supported by Grant R03AI131011-01A1 from NIAID Abbreviations APC Antigen presenting cells CAMs Cellular adhesion molecules CD Crohn’s Disease GWAS Genome-wide association studies IBD Inflammatory Bowel Diseases IEC intestinal epithelial cells JAK Janus kinases Mayo C”