Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
By Y. Lee, J. Menezes, Y. Umesaki, S. Mazmanian. Proceedings of the National Academy of Sciences of the United States of America, 2010
1,277 citations recorded by the source corpus.
Subfields: Gastroenterology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3c50fe9850aa6baf1d0df38571f9288e8e0c376e
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Citations in the corpus
- Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters (2015, background): “demonstrated that EAE-resistant germ-free mice develop EAE spontaneously without any manipulation with adjuvant or pertussis toxin after recolonization with indigenous bacteria or a strain of segmented filamentous bacteria [9,10].”
- The Microbiome in Infectious Disease and Inflammation (2012, positive): “Accumulating evidence suggests that a change in the gut microbiota composition has a key role not only in IBD, but also in the development of systemic immune diseases, such as rheumatoid arthritis (15, 16), encephalomyelitis (17, 18), type 1 diabetes (19, 20), and allergic diseases (21, 22).”
- NLRP6 inflammasome is a regulator of colonic microbial ecology and risk for colitis (2011, neutral): “In some autoimmune models, germ-free conditions or inoculation with a microbiota from healthy mice ameliorates disease (Lee et al., 2010; Mazmanian et al., 2008; Sinkorová et al., 2008; Wu et al., 2010).”
- Interaction between the gut microbiome and mucosal immune system (2017, neutral): “experimental autoimmune encephalomyelitis [67].”
- The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide (2013, background): “Finally, monoassociation of tumor-bearing GF mice with SFB, which promotes Th17 cell differentiation in the LP (1, 13, 14) also had a detrimental impact on the tumor growthinhibitory effect of CTX (Fig.”
- Homeostatic immunity and the microbiota (2017, neutral): “…SFB-specific Th17 response, a phenomenon that has been associated both with its ability promote protection against gastrointestinal pathogens (Ivanov et al., 2009), but also mediate profound systemic effects in the context of inflammation (Lee et al., 2011; Wu et al., 2010; Yang et al., 2014).”
- Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “In MS, studies in animal models and in germ-free mice (Forsythe et al., 2013; Lee et al., 2011) showed that GMB modifications may cause the activation of immune and inflammatory responses that can extend beyond the gut, up to the brain.”
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, positive): “Depending on the experimental model, pro-and anti-inflammatory effects of the commensal flora have been recently reported 57,58,14,15,59 highlighting the need to identify the molecular mechanisms by which the commensal flora regulates the immune response.”