Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
By K. Petersen, D. Befroy, S. Dufour, J. Dziura, C. Ariyan, D. Rothman, Loretta DiPietro, G. Cline, Gerald I. Shulman. Science, 2003
2,143 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/5ddb8d6bbdc42f1f9f6c07188868cc0d21fe10e9
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In Molecular Biology
- Ralph DeFronzo
- B. Spiegelman
- Gerald I. Shulman
- R. Scarpulla
- Christoph Handschin
- Muhammad Abdul-Ghani
- Jiandie D. Lin
- Johan Auwerx
In Physiology
- B. Spiegelman
- Ralph DeFronzo
- Gerald I. Shulman
- R. Scarpulla
- Johan Auwerx
- Christoph Handschin
- V. Samuel
- Jiandie D. Lin
Citations in the corpus
- Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021, background): “Aging also impairs subcutaneous adipose tissue function, possibly because of accumulation of senescent adipocytes, impaired pre-adipocyte development (Palmer and Kirkland, 2016), and reduced mitochondrial activity (Lee et al., 2010; Petersen et al., 2003), which is associated with increases in ectop”
- Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “…that mitochondrial dysfunction is strongly associated with pathological conditions such as inflammation, IR, Frontiers in Physiology | www.frontiersin.org 9 January 2020 | Volume 10 | Article 1607 and T2D (Silva et al., 2000; Petersen et al., 2003, 2004; Morino et al., 2005; Woo et al., 2019).”
- Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. (2006, background): “This indicates an association between age-related decline in mitochondrial function and insulin resistance (Petersen et al., 2003).”
- Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “Impairment of mitochondrial oxidative metabolism has also been observed in age-related insulin resistance (Petersen et al., 2003).”
- Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, background): “A reduction in PGC-1α function is associated with mitochondrial dysfunction, reduction in fatty acid oxidation and risk for insulin resistance or type 2 diabetes (11-14).”
- The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. (2016, background): “Ageassociated reductions in mitochondrial function may be due to cumulative damage from ROS (50).”