The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.

By V. Samuel, Gerald I. Shulman. Journal of Clinical Investigation, 2016

1,184 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/528852e38dc57611cbcdfd87783ce65b7a7ba08b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. Jian Li
5. D. Luciani
6. A. Chaudhry
7. G. Targher
8. Rocky Shi

In Physiology

1. M. Hill
2. Guanghong Jia
3. J. Sowers
4. G. Targher
5. Barry J. Goldstein
6. Rosario Scalia

Citations in the corpus

• Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations (2022, background): “Studies have suggested that increased TG levels can induce elevated free fatty acid (FFA) levels and promote the increased flux of FFAs from adipose tissue to non-adipose tissue, which may accompany IR [70].”
• Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus (2020, background): “Normal insulin signal transduction (IST) has complex sequential steps involving different enzymes and mediators, which results in facilitated glucose entry into the adipocytes, muscles, and myocardial cells via GLUT-4 (glucose transporter4) transporters [8, 34].”
• Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity (2018, background): “obese humans can be correlated to elevated diacylglycerol content and PKC ε (protein kinase Cε) activation.(60) Diacylglycerol increases lipid-associated endoplasmic reticulum stress.”
• A pipeline for multidimensional confocal analysis of mitochondrial morphology, function and dynamics in pancreatic β-cells (2019, background): “Perturbations to mitochondria 66 are also a common feature in insulin target tissues with impaired insulin signaling (11, 12).”
• Non-Alcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases (2017, neutral): “A complete accounting for all the pathways that regulate hepatic lipid and glucose metabolism is beyond the scope of this review and was recently reviewed in greater detail elsewhere (Samuel and Shulman, 2016).”
• Insulin resistance: Review of the underlying molecular mechanisms (2018, background): “IR is a complex pathological state of inappropriate cellular response to insulin hormone in insulin‐dependent cells such as adipocytes and cardiomyocytes (Samuel & Shulman, 2016).”
• Triglyceride metabolism in the liver (2017, neutral): “Under fasting conditions when plasma insulin concentrations are low, a lipolytic program is initiated in white adipose tissue, which increases the plasma FA pool that is available for uptake by the liver (12,214) (Fig.”
• Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence? (2018, background): “The key role of hepatic ceramides in the development of IR has been reviewed elsewhere.(170) Experimental”
• Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “In order to combat insulin resistance, the body increases the production of insulin to maintain euglycemia leading to an increase in the size of islet cells and pancreatic β-cells [23].”