Macrolides and community-acquired pneumonia: is quorum sensing the key?
By Matt P. Wise, D. W. Williams, Michael A O Lewis, Paul J Frost. Critical Care, 2010
846 citations recorded by the source corpus.
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs.
Subfields: Epidemiology, Infectious Diseases, Microbiology
View Paper: https://www.semanticscholar.org/paper/5c513d71a1dafbddf580064f450ee37e9c515e52
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