Hypoxia and cancer

By M. Brahimi-Horn, J. Chiche, J. Pouysségur. Journal of molecular medicine, 2007

845 citations recorded by the source corpus.

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Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011, background): “5 minutes before with DiOC7(3) (70 mL, 0.”
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “While HIF1 protein is clearly stabilized and accumulates to a higher degree in the nuclear fraction of hypoxic adipose tissue, we examined whether this nuclear HIF1 effectively stimulates a proangiogenic program, similar to what many reports in the literature have described (1).”
Defining the Role of Hypoxia-Inducible Factor 1 in Cancer Biology and Therapeutics (2009, neutral): “Human cancers frequently contain areas of necrosis in which cancer cells have died due to inadequate oxygenation (Harris, 2002; Brahimi-Horn et al., 2007).”