Hypoxia-induced autophagy: cell death or cell survival?

By N. Mazure, J. Pouysségur. Current Opinion in Cell Biology, 2010

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How researchers see this paper

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The Roles of Autophagy in Cancer (2018, background): “Under hypoxia conditions, HIF-1α induces activation of autophagy in cancer progression [94] and regulates many of its target genes [95].”
The Role of Autophagy in Cancer: Therapeutic Implications (2011, neutral): “cells within hypoxic tumor regions (3).”
Autophagy and autophagy-related proteins in cancer (2020, background): “nutrient starvation including depletion of total amino acids and serum starvation that strongly induces a high level of autophagy [27], oxidative stress that induces autophagy in order to recycle damaged organelles (e.”
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “Autophagy is achieved by decreasing oxidative metabolism.(15,16) On the contrary, others have shown that cycling hypoxia led to increased reactive oxygen species (ROS) production, what contributed to tumor cell survival and progression.”
Autophagy and the integrated stress response (2010, positive): “These include the protein DJ-1 (also called CAP1/RS/PARK7, which regulates autophagy by an unknown mechanism), the autocrine stimulation of a PDGFR-dependent pathway, the stimulation of AMPK through metabolic stress, and the UPR of the ER (Mazure and Pouyssegur, 2010).”