A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

By Hisashi Tamaru, E. Selker. Nature, 2001

1,052 citations recorded by the source corpus.

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Citations in the corpus

• Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase (2002, background): “Although the relationship between these chromatin modifications is generally unknown, in the fungus Neurospora crassa , DNA methylation acts genetically downstream of H3 Lys 9 methylatio”
• Epigenetics in human disease and prospects for epigenetic therapy (2004, background): “1 ), where H3-K9 methylation is a prerequisite for DNA methylatio”
• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “Most markedly, methylation of histone H3 at Lys9, which is clearly linked to gene silencing, has been shown to be essential for DNA methylation in the fungus Neurospora crassa”
• The diverse functions of histone lysine methylation (2005, background): “Interestingly, genetic studies have shown in a number of organisms that H3-K9 methylation is a prerequisite for DNA methylation 128–130 .”
• DNA methylation patterns and epigenetic memory. (2002, background): “Whereas histone H3 tails modified by methylation on Lys 9 might recruit DNA methyltransferases (Tamaru and Selker 2001), modifications associated with active chromatin, such as acetylation of H3 or H4 or methylation of Lys 4 of histone H3, may actively exclude these enzymes.”
• DNA methylation and cancer. (2010, background): “For example, in Neurospora crassa DNA methylation depends on the methylation of histone 3 at lysine 9 (H3K9) and only this modification can trigger epigenetic gene repression (Tamaru and Selker, 2001).”
• LaeA, a Regulator of Secondary Metabolism in Aspergillus spp (2004, background): “Well-known protein methyltransferases include histone and arginine methyltransferases that play important roles in the regulation of gene expression in eukaryotes, in part through modification of the chromatin structure (15, 25, 35).”
• The fundamental role of epigenetic events in cancer (2002, background): “In these organisms, mutations in a Lys9 histone methyltransferase eliminate all or some DNA methylatio”
• Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “Conversely, in Neurospora crassa , inactivation of DIM5, which is related to the H3K9 methyltransferase SU(VAR)3-9, or mutation of H3K9 led to decreased DNA methylatio”
• The role of RNA interference in heterochromatic silencing (2004, background): “In Neurospora crassa , DNA methylation depends on the Su(var)3-9 lysine 9 methyltransferase Dim-5 (ref”