DNA methylation and cancer.

By M. Kulis, Manel Esteller. Advances in Genetics, 2010

736 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Genetics and biology of prostate cancer (2018, background): “DNA can be methylated by canonical DNA methyltransferase (DNMT) consisting of DNMT1, DNMT3A, and DNMT3B at the five position of the cytosine within CpGdinucleotides, which are often found in large clusters called CpG islands (Kulis and Esteller 2010; Lyko 2018).”
The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “This includes alterations in DNA methylation [55], histone modifications [56], and expression of miRNAs [57] and lncRNAs [58,59].”
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials (2019, background): “On the other hand, methylation of DNA can also be a barrier for certain transcription factors to bind to promoter sites such as AP-2, c-Myc, CREB/ATF, E2F, and NF-kB.(13) As for methyl-group binding proteins, many studies have investigated their roles in various cancers, but the mechanism underlying”
Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “Furthermore, the hypermethylated states seen in many tumor cells via changes in one-carbon metabolism ensures that sustained epigenetic effects will silence the expression of many key genes, including tumor suppressors (255).”