Controlling the double helix

By G. Felsenfeld, Mark Groudine. Nature, 2003

1,225 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5a933f232118106809085d0203c00f2586983ae9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004, background): “It is now well established that posttranslational acetylation, methylation, phosphorylation, and ubiquitination of histones play an intrinsic role in transcriptional regulation and are potentially involved in the propagation of the transcriptional state through cell division (Turner 2002; Felsenfeld”
Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation (2007, background): “Much recent research emphasizes that transcriptional regulation involved in memory requires the coordinated interaction of multiple transcription factors and transcriptional coactivators in the context of chromatin (Felsenfeld and Groudine, 2003; Korzus 2003; Harbison et al., 2004).”
Combinatorial patterns of histone acetylations and methylations in the human genome (2008, background): “154" language="eng" relation="no"> Histones are characterized by numerous posttranslational modifications that influence gene transcriptio”
Dynamic reprogramming of chromatin accessibility during Drosophila embryo development (2011, background): “The formation of active cis-regulatory complexes involves the dynamic interplay between sequence-specific DNA binding proteins and nucleosomes and chromatin organizing proteins [16-20].”
Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, neutral): “There are also several comparative studies of histone evolution (Sandman et al. 1998; Felsenfeld and Groudine 2003), and the evolution of RNAi systems for defence against genomic parasites and as regulators in an ancient RNA world has been suggested (Cerutti and Casas-Mollano 2006).”
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. (2003, background): “Chromatin structure contains the molecular imprint underlying cell memory and epigenetic inheritance, and emerging evidence suggests that covalent modifications of histones play a major role as carriers of epigenetic information (Felsenfeld and Groudine 2003).”
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action (2006, background): “Post-translational modification of histones, a form of chromatin remodeling, can alter the chromatin architecture at promoter regions by controlling their permissiveness for transcriptio”
Rethinking how DNA Methylation Patterns are Maintained (2009, background): “Indeed, there are several examples of chromatin-modifying enzymes that remain associated with their product — for example, EZH2 remains associated with histone H3 trimethylated at lysine 27 — which suggests that this mechanism is common and may be responsible for the inheritance of epigenetic state”
Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “These data sets can be represented as single tracks that can be plotted along the genome and compared to other genomic features such as DNase I hypersensitive sites (which are hallmarks of gene regulatory elements 23 ) or genes.”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “Changes enacted by chromatin remodelers, such as nucleosome eviction or insertion, as well as the addition or deletion of histone modifications, have been linked to changes in the expression of nearby genes (Cirillo et al., 2002; Felsenfeld and Groudine, 2003).”
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops (2004, background): “Higher-order chromatin structure is essential to nuclear architecture, enabling transcription and replicatio”
Circadian regulator CLOCK is a histone acetyltransferase. (2006, neutral): “Several histone modifications contribute to chromatin remodeling and thereby to the control of a large array of nuclear processes (Cheung et al., 2000; Felsenfeld and Groudine, 2003).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “Post-translational modifications (e.g., acetylation, phosphorylation, methylation) of histones at the promoters of particular genes, and methylation of DNA, may activate or suppress gene expression for long periods of time (Felsenfeld & Groudine 2003).”