Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

By C. Vecsey, Joshua D. Hawk, K. Lattal, J. Stein, S. Fabian, Michelle A. Attner, Sara M Cabrera, Conor B McDonough, Paul K. Brindle, Ted Abel and 1 more. Journal of Neuroscience, 2007

810 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e051d901d8258b9a06261e22311aa16d804f5c0e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Peter W. Kalivas
2. C. O'Brien
3. Helen S. Mayberg
4. Alvaro Pascual-Leone
5. B. Kolb
6. Douglas A. Baxter
7. John H. Byrne
8. Paul Smolen

In Genetics

1. C. O'Brien
2. Leslie M. Thompson
3. Peter W. Kalivas
4. Ted G. Dinan
5. G. Clarke
6. A. Kazantsev
7. C. Alberini
8. J. Cryan

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. R. Stilling
6. M. van de Wouw
7. Alvaro Pascual-Leone
8. B. Kolb

Citations in the corpus

• Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, positive): “(243) showed that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by CREB and the recruitment of CBP via the CREB-binding domain of the coactivator CBP.”
• The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems (2015, background): “One of the main product of bacterial metabolism are short-chain fatty acid (SCFAs), such as butyric acid, propionic acid and acetic acid, that are able to stimulate sympathetic nervous system [49], mucosal serotonin release [50] and to influence memory and learning process [51,52].”
• Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “Given the ubiquitous roles of CBP and p300 in all tissues, and the recent data suggesting an improvement in long-term memory and synaptic plasticity by the HDAC inhibitor trichostatin A (TSA) through its effect on CBP and CRE”
• Harnessing neuroplasticity for clinical applications (2011, positive): “Pharmacotherapies can increase neuroplasticity through molecular manipulation of numerous cellular and synaptic pathways, such as HDAC inhibitors, mTOR inhibitors and trkB agonists (Vecsey et al., 2007; Potter et al., 2010).”
• How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “Histone acetylation is increased after fear conditioning in the hippocampus and amygdala, in part via recruitment of CREB together with its coactivator, CREB binding protein (CBP), which is a histone acetyltransferase (Vecsey et al. 2007).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, methodology): “(2004), sodium butyrate was used to facilitate neuronal plasticity, long-term memory formation or LTP (Lattal et al., 2007; Vecsey et al., 2007), e.”