Rethinking how DNA Methylation Patterns are Maintained

By Peter A. Jones, G. Liang. Nature reviews genetics, 2009

793 citations recorded by the source corpus.

DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4f05acbe8c45c58adeda8e8915afb314133ed0da

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Citations in the corpus

Epigenetic Determinants of Cancer. (2016, result): “Studies in other cancer cell types have produced more variable results (Leu et al. 2003; Jones and Liang 2009).”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Unlike DNMT1, DNMT3A and DNMT3B are firmly anchored to nucleosomes, perhaps allowing these enzymes to remain closely associated with the DNA methylation that they produce to facilitate epigenetic inheritanc”
Gene Body Methylation can alter Gene Expression and is a Therapeutic Target in Cancer (2014, background): “See also Figure S4. consistent with DNMT1 functioning mainly, although not exclusively, as a maintenance enzyme (Jones and Liang, 2009).”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “Although there is increasing evidence that DNMT3A and DMNT3B are also involved in the maintenance of DNA methylation (61), the activity of the maintenance DNMT, DNMT1, ensures that DNA methylation patterns are stably maintained during adult life.”
Epigenetic modifications and human disease (2010, background): “However, the division of labor between de novo and maintenance methylation is not always so clear, and a revised model has recently been proposed by Jones and Lian”
Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “However, increasing evidence supports the idea that all three mammalian DNA methyltransferases are involved in DNA methylation maintenanc”
The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome (2013, background): “3358 Cell Cycle Volume 12 issue 21 maintenance methyltransferase DNMT1, which acts predominantly on hemimethylated CpG sites arising during DNA replication, and the DNA methyltransferases DNMT3A and DNMT3B, which operate in de novo methylation of previously unmethylated CpG sequences but also in the”
Chromatin replication and epigenome maintenance (2012, background): “For the maintenance DNA methyltransferase DNMT1, this involves UHRF1 (also known as NP95), a multi-domain protein that binds hemimethylated CpGs and directs DNMT1 to these sites (reviewed in Ref”