Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

By Nadia M. Tsankova, O. Berton, W. Renthal, Arvind Kumar, Rachel L. Neve, E. Nestler. Nature Neuroscience, 2006

1,781 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96cef032615021f2027c66c0f926681dcbc5fe13

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. E. Nestler
2. V. Krishnan
3. J. Cryan
4. R. Duman
5. Ted G. Dinan
6. R. Stilling
7. S. Russo
8. Eero Castrén

In Genetics

1. E. Nestler
2. V. Krishnan
3. E. Olson
4. Leslie M. Thompson
5. H. Schmidt
6. R. Duman
7. Ted G. Dinan
8. A. Kazantsev

In Molecular Biology

1. J. Cryan
2. E. Nestler
3. Ted G. Dinan
4. V. Krishnan
5. R. Stilling
6. R. Duman
7. E. Olson
8. H. Schmidt

Citations in the corpus

• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, neutral): “In either case, the model employs a naturalistic social stress-induced behavior that is quantifiable and amenable to experimental manipulation (12-14,42-50).”
• Brain foods: the effects of nutrients on brain function (2008, neutral): “A recent study in rodents demonstrated that defeat stress, an animal model of depression, induced a lasting repression of BDNF transcripts, whereas antidepressant treatment reversed this repression by inducing histone acetylatio”
• Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “Antidepressant drugs seem to affect BDNF through epigenetic mechanisms that include downregulation of histone deacteylas”
• Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “It was recently shown that epigenetic modifications may influence antidepressant upregulation and stress-induced downregulation of BDNF transcription from specific exons (Tsankova et al, 2006).”
• The Influence of Exercise on Cognitive Abilities (2013, neutral): “For example, depression-like behavior in mice results in methylation of histone H3 and long-lasting suppression of BDNF transcription through promoters IV and VI (181).”
• New insights into BDNF function in depression and anxiety (2007, background): “For example, multiple promoters drive Bdnf transcription, and antidepressants seem to act selectively at some promoters, but not other”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “As such, chronic administration of the antidepressant drug imipramine induced HDAC5-mediated differential histone acetylation in the hippocampus of mice undergoing chronic defeat stress (Tsankova et al. 2006).”
• Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “HDACs, particularly HDAC5, seem to mediate antidepressant activity in animal studie”