Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
By A. Murrell, S. Heeson, Wolf Reik. Nature Genetics, 2004
599 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/e86e298070ab44d7e3e563b604faac7763b2c947
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In Genetics
In Molecular Biology
In Pediatrics, Perinatology and Child Health
Citations in the corpus
- CTCF: Master Weaver of the Genome (2009, unknown): “Reik, Ohlsson, and colleagues first reported CTCF loops at this locus using an elegant transgenic model that enables detection of parent-of-origin chromatin interactions in cells derived from mouse fetal liver (Kurukuti et al., 2006; Murrell et al., 2004).”
- Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, background): “On the paternal allele, the interaction between the Igf2 gene and the methylated ICR brings the Igf2 gene close to enhancer elements and leads to expression of Igf2 from this allel”
- Child health, developmental plasticity, and epigenetic programming. (2011, background): “The mechanism of imprinting at the H19 ICR involves formation of an insulator on the unmethylated allele, which prevents the IGF2 promoter from interacting with downstream enhancers and consequently prevents IGF2 expression from the maternal chromosome (265, 266).”
- Long Noncoding RNAs (2015, background): “Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE et al (1993) Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.”
- Beyond the sequence: cellular organization of genome function. (2007, unknown): “Chromatin loops may also contribute to gene silencing, as looping of imprinting-specific regions occurs parent specifically in the insulin-like growth factor 2, H19 gene cluster (Murrell et al., 2004), and the maternally expressed DLX5 locus (Horike et al.”
- Quantitative analysis of chromosome conformation capture assays (3C-qPCR) (2007, methodology): “To further validate the 3C-qPCR protocol, we analyzed the enhancers/promoter interaction at the imprinted H19 locus on mouse chromosome 7, which is a mammalian locus recently analyzed by 3C assays using the standard procedur”