Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

By Antonio J. Giráldez, Yuichiro Mishima, J. Rihel, R. Grocock, Stijn van Dongen, Kunio Inoue, Anton J. Enright, A. Schier. Science, 2006

1,713 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/59d54a14b1a31a0cee17ca75b97e41e924aa6082

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Citations in the corpus

Identifying miRNAs, targets and functions (2012, background): “Therefore, most algorithms apply the cross-species conservation requirement to reduce the number of false positives, despite some risk of increasing false negatives as some miRNAs, such as miR-430 [44], lack conserved targets.”
Metazoan MicroRNAs (2018, background): “…examine the molecular effects of perturbing a miRNA family not only confirm repression of many mRNAs with conserved sites but also reveal repression of even more mRNAs with non-conserved seed-matched sites (Krutzfeldt et al., 2005; Lim et al., 2005; Giraldez et al., 2006; Rodriguez et al., 2007).”
Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing (2010, background): “…or deleting an endogenous miRNA leads to modest yet detectable changes in the output of hundreds of genes containing seed sites in their 3’UTRs (Krutzfeldt et al., 2005; Lim et al., 2005; Giraldez et al., 2006; Grimson et al., 2007; Rodriguez et al., 2007; Baek et al., 2008; Selbach et al., 2008).”
Getting to the root of miRNA-mediated gene silencing. (2008, background): “More recently, however, several reports showed that animal miRNAs do induce significant degradation of target mRNAs (Bagga et al., 2005; Wu and Belasco, 2005; Behm-Ansmant et al., 2006; Giraldez et al., 2006; Wu et al., 2006; Chendrimada et al., 2007; Eulalio et al., 2007a).”
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. (2009, background): “Different degrees of destabilization appear to apply to the majority of mRNA targets, as demonstrated by microarray analyses of transcript levels in cells and organs in which the miRNA pathway was inhibited or in which miRNA levels were experimentally increased or decreased [26,54,58,60,61,64–69].”
How do microRNAs regulate gene expression? (2008, background): “In mutant embryos that do not express the miR-430 microRNAs, deadenylation and degradation of the maternal transcripts still occurred but were delayed, which led to abnormalities in brain development ( 51 ).”
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “Previous studies indicate that miRNAs can reduce the levels of the targeted transcripts, and not just the expression of the translated protein (Bagga et al. 2005, Lim et al. 2005; Giraldez et al. 2006; Rehwinkel et al. 2006; Wu et al. 2006).”
The maternal-to-zygotic transition: a play in two acts (2009, background): “For example, the zygotic expression of miR-430 in zebrafish embryos is responsible for the clearance of several hundred maternal messages (Giraldez et al., 2006). miR-430 requires additional, zygotically produced, nonmiRNA factors to degrade a subset of its targets (Ferg et al., 2007).”
Predicting effective microRNA target sites in mammalian mRNAs (2015, methodology): “D, Figure 6I,J GSM538818, GSM538819, GSM538820, GSM538821 (Hafner et al., 2010) Figure 1G GSM156524, GSM156532, GSM210897, GSM210898, GSM210901, GSM210903, GSM210904, GSM210907, GSM210909, GSM210911, GSM210913, GSM37599, http://psilac.mdc-berlin.de/download/ (let7b_32h, miR-30_32h, miR-155_32h, miR-”
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp™ (2014, background): “, 2009), miRNAs also repress many additional mRNAs with nonconserved MREs (Farh et al., 2005; Krützfeldt et al., 2005; Giraldez et al., 2006; Baek et al., 2008), and high-throughput crosslinking identifies many additional binding sites that would not be classified as MREs because they don’t mediate ”