Identifying miRNAs, targets and functions

By Bing Liu, Jiuyong Li, Murray J. Cairns. Briefings Bioinform., 2012

544 citations recorded by the source corpus.

microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets and further inferring miRNA functions have been a critical strategy for understanding normal biological processes of miRNAs and their roles in the development of disease. In this review, we focus on computational methods of inferring miRNA functions, including miRNA functional annotation and inferring miRNA regulatory modules, by integrating heterogeneous data sources. We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3f93daea46527a67c1f350b8969b648fff1ac627

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Nathan Wong
2. Xiaowei Wang
3. Yuhao Chen
4. Jiuyong Li
5. Murray J. Cairns
6. Bing Liu

In Molecular Biology

1. Nathan Wong
2. Xiaowei Wang
3. Yuhao Chen
4. Murray J. Cairns
5. Jiuyong Li
6. Bing Liu

Citations in the corpus

• miRDB: an online resource for microRNA target prediction and functional annotations (2014, background): “The discovery of a large number of miRNAs presents grand new opportunities to uncover the complexity of gene expression regulatory networks (12).”