Coping with stress: eIF2 kinases and translational control.

By R. Wek, H.Y. Jiang, T. Anthony. Biochemical Society Transactions, 2006

1,392 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/59c1b168c34952f60d26c6277621b0dbafc548ab

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Citations in the corpus

The integrated stress response (2016, positive): “The mouse gene contains two uORFs (uORF1 and uORF2) that are located 5 0 to the Atf4 CDS (Fig 2), while human ATF4 mRNA contains three upstream open reading frames (uORF1, uORF2, and uORF3) [142].”
From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health (2007, neutral): “to manage stress conditions effectively (140, 327).”
Eukaryotic stress granules: the ins and outs of translation. (2009, background): “For example, phosphorylation of eIF2a underlies the decrease in translation initiation required for stress granule assembly in many stress responses (Wek et al., 2006), while phosphorylation of TTP, BRF1, and G3BP reduces their accumulation in stress granules (Stoecklin et al.”
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, background): “In other cells, GCN2 is known to activate a downstream stress-response pathway, resulting in a coordinated program of changes in gene expression (26, 33).”
Indoleamine 2,3-dioxygenase and tumor-induced tolerance. (2007, background): “However, since IDO-express-ing APCs and responding T cells are obliged to be in close physi - cal contact, it might be that tryptophan concentrations can be lowered sufficiently in T cells interacting with the IDO-express-ing APCs to activate the GCN2 signaling pathway.”
Endoplasmic reticulum stress in disease pathogenesis. (2008, background): “Phosphorylation of eIF2α, by kinases such as PERK, inhibits its function (19, 20).”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “The other three, protein kinase R (PKR), heme-regulated eIF2a kinase (HRI), and PKR-like kinase (PERK), are activated by diverse stimuli [reviewed in (287)].”
Pharmacological brake-release of mRNA translation enhances cognitive memory (2013, background): “…molecular event. eIF2α phosphorylation results in an attenuation of translation with consequences that allow cells to cope with the varied stresses (Wek et al., 2006). eIF2 (which is comprised of three subunits, α, β and γ) binds GTP and the initiator Met-tRNA to form the ternary complex…”
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression (2013, background): “Reversible phosphorylation on serine 51 of the a subunit of eukaryotic translation initiation factor 2 (eIF2a) is a highly conserved regulatory event activated in response to diverse stresses (3).”