The integrated stress response

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The Unfolded Protein Response and Cell Fate Control. (2017, positive): “…eIF2a phosphorylation represents a convergence point of different stress pathways known as the ‘‘integrated stress response,’’ which is governed by specific kinases that are activated by inflammation, viral infections, nutrient deprivation, and heme deficiency (Pakos-Zebrucka et al., 2016).”
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals (2017, background): “Surprisingly, canonical mitochondrial unfolded protein response genes mediated by ATF5 are not activated.”
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer (2018, background): “Phosphorylated eIF2α then inhibits the translation of many mRNAs, including ATF4 uORFs, thus liberating ATF4 mRNA translation and resulting in an increase of ATF4 protein levels [48].”