From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health

By L. Papp, Jun Lu, A. Holmgren, Kum Khanna. Antioxidants and Redox Signaling, 2007

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Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors (2019, background): “As opposite, selenium, which is an essential micronutrient [97, 98], has been inversely associated with several cancers including pancreatic [99-103], while only a small study published in 1989 showed an increased risk of pancreatic cancer due to high selenium levels [104]; however, no replication s”
Selenium in Human Health and Disease (2011, neutral): “Three TXNRDs have been identified in mammals: TXNRD1 in the cytosol=nucleus, TXNRD2 in mitochondria, and thioredoxin glutathione reductase in the testis, with the last also possessing glutathione and glutaredoxin reductase activity (279).”
Food-chain selenium and human health: emphasis on intake (2008, background): “Selenoprotein synthesis is a complex process requiring multiple factors for the successful insertion of Se as selenocysteine, many of which are encoded by polymorphic genes((136)).”
Selenium in agriculture: a nutrient or contaminant for crops? (2014, background): “The selenol group (SeH) of selenocysteine in thioredoxine reductases plays an important role in protection against free radicals (Papp et al. 2007).”