The functional role of long non-coding RNA in human carcinomas

By E. Gibb, Carolyn J. Brown, Wan L. Lam. Molecular Cancer, 2011

1,667 citations recorded by the source corpus.

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/30fadadba95fee4bfaeaf0bdac3cabca3a5577f3

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Citations in the corpus

Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “Intergenic lncRNAs regulate gene expression through modifying the chromatin complexes or RNA binding proteins and their aberrant expression is associated with cancer [96].”
The Landscape of long non-coding RNA classification (2015, neutral): “We discuss here only examples of functions used for classification, and direct the reader to other reviews focusing on lncRNA molecular mechanisms [6, 7, 13, 24, 39, 107].”
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer (2017, background): “As such, when the expression of these lncRNAs is decreased, the expression of genes under their control becomes altered and cells develop resistance to apoptosis, thereby increasing their proliferation [87].”
DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs (2012, background): “Moreover, they may also perform cis-regulatory actions, as they are usually located near protein-coding genes (7), while, putative direct interactions of lncRNAs with protein-coding genes and other RNA molecules have already been suggested (1,3).”
Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “Human lncRNAs participate in a spectrum of biological processes, for example, epigenetics, nuclear import, alternative splicing, RNA decay and translation [2,13].”
MEG3 noncoding RNA: a tumor suppressor (2012, background): “However, recent studies reveal that another class of genes, whose products are long noncoding RNAs (lncRNAs) with sizes O200 nt, may also play an important role in tumor suppression (Gibb et al. 2011).”
The emergence of lncRNAs in cancer biology (2011, background): “lncRNAs also commonly exhibit splicing of multiple exons into a mature transcript, as do many antisense RNAs, but not RNAs Small ncRNAs The diversity of small ncRNAs has perhaps grown the most; several dozen classes of small ncRNAs have been proposed (10, 11).”
LncRNA-mediated regulation of cell signaling in cancer (2017, background): “…capable of producing functional small peptides (Anderson et al 2015, Nelson et al 2016). ncRNAs were initially considered as transcriptional noises (Gibb et al 2011), however, it has become increasingly apparent that they may play a critical role in diverse cellular processes from normal…”