TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

By F. Yarovinsky, Dekai Zhang, J. Andersen, G. Bannenberg, C. Serhan, M. Hayden, S. Hieny, F. Sutterwala, R. Flavell, S. Ghosh and 1 more. Science, 2005

1,079 citations recorded by the source corpus.

Subfields: Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/57b490429c79ab52d019d1ce92e6d650a3e60a5f

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. S. Ghosh
4. O. Takeuchi
5. M. Hayden
6. Satoshi Uematsu
7. A. West
8. S. Lehnardt

Citations in the corpus

• Toll-Like Receptor Signaling Pathways (2014, background): “TLR11 is localized in the endolysosome and recognizes flagellin (21) or an unknown proteinaceous component of uropathogenic Escherichia coli (UPEC) as well as a profilin-like molecule derived from Toxoplasma gondii (22).”
• Macrophage activation by endogenous danger signals (2008, background): “TLRs and ligands TLR1 Tri-acyl lipoprotein Cell surface MyD88/Mal TLR2 Gram-positive peptidoglycan and lipoteichoic acid; fungi zymosan; Cell surface MyD88/Mal mycobacteria lipoarabinomannan; Trypanosoma cruzi glycoinositolphospholipids; Treponema maltophilum glycolipids; Neisseria porins; viral gly”
• Pathogen recognition and innate immunity. (2006, positive): “Uropathogenic bacteria are recognized by mouse TLR11, although the specific components that are responsible for this activation have not been identified (Zhang et al., 2004).”
• NF-κB and the immune response (2006, background): “…TLR9 has been reported to recognize the malarial pigment hemozoin, a byproduct of heme metabolism in infected erythrocytes (Coban et al., 2005) whereas TLR11 recognizes a profilin-like protein that is conserved in apicomplexan parasites including Toxoplasma gondii (Yarovinsky et al., 2005).”
• The Role of TLR2 in Infection and Immunity (2012, background): “Strong IL-12 induction through TLR11 is protective and part of the murine immune response, but since this gene is not functional in humans, other TLRs can have a different role in this host (Yarovinsky et al., 2005).”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “TLR11 also recognizes the profilin-like molecule derived from Toxoplasma gondii”
• Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “Finally, TLR11 is the receptor for uropathogenic bacteria and a profilin-like protein derived from the parasite Toxoplasma gondii (Yarovinsky et al., 2005; Zhang et al., 2004).”