High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism1

By M. Ziółkowska, A. Koc, Grazyna Luszczykiewicz, K. Ksiezopolska-Pietrzak, E. Klimczak, H. Chwalińska-Sadowska, W. Maslinski. Journal of Immunology, 2000

666 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/57acb68b36f62cf905bd46b5a03e48fe9bda0755

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Cua
2. Y. Iwakura
3. R. Kastelein
4. Brent S. McKenzie
5. T. Mcclanahan
6. W. Blumenschein
7. Yi Chen
8. S. Nakae

In Oncology

1. D. Cua
2. M. Karin
3. Wan-Wan Lin

In Rheumatology

1. C. A. Dinarello

Citations in the corpus

• Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation (2003, background): “IL-17 is a potent proinflammatory cytokine produced by PBMCs/T cells and by cells isolated from synovial fluid of rheumatoid arthritis patients (27).”
• IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger (2003, background): “In this context, IL-15 was a likely candidate, because this cytokine, which can be produced in the airways by inflammatory cells such as macrophages and neutrophils (37), has been shown to be a potent trigger that leads to production of IL-17 (26).”
• Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1 (2003, background): “Involvement of IL-17 in the development of RA is suggested, because IL-17 is found in the synovial fluid of RA patients (10) and is produced by T cell clones established from RA patients (11).”
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005, background): “In addition, IL-17 has been found in many human autoimmune diseases, including multiple sclerosis (30), rheumatoid arthritis (31), and psoriasis (32).”
• IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection1 (2007, background): “The macrophage/DC-derived cytokines IL-23 and IL-15 have been reported to induce IL-17 production (28, 43).”
• Th17 cells in human disease (2008, background): “Stimulation of PBMCs collected from patients with gingivitis and periodontitis by the outer membrane protein (OMP) of Porphyromonas gingivalis, a causative microorganism in periodontal disease, led to OMPinduced expression of IL-17 (207).”
• IL‐12 and IL‐23: master regulators of innate and adaptive immunity (2004, background): “IL-17 has been found in many human autoimmune diseases, including MS (79), rheumatoid arthritis (80), and psoriasis”
• Interleukin-17 family and IL-17 receptors. (2003, background): “Arthritis Synovial fluid cytokine levels ↑ IL-17, IL-15 in RA but not OA patients ↑ IL-17A mRNA in PBMC by IL-15, IL-2, PMA + ionomycin LPS, TNF- , IL-8, IL-6 do not affect IL-17A mRNA in PBMC [12]”