Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice 1

By S. Nakae, Aya Nambu, K. Sudo, Y. Iwakura. Journal of Immunology, 2003

1,424 citations recorded by the source corpus.

Subfields: Oncology, Radiology, Nuclear Medicine and Imaging, Rheumatology

View Paper: https://www.semanticscholar.org/paper/dc29a2f6aa07a43830e9bbb05f9f236c3ac28746

How researchers see this paper

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In Oncology

1. D. Cua
2. N. Restifo
3. C. Dong
4. Dan R. Littman
5. Shizuo Akira
6. S. Rosenberg
7. Taro Kawai

In Radiology, Nuclear Medicine and Imaging

1. Yu Wang

In Rheumatology

1. Shizuo Akira
2. C. A. Dinarello

Citations in the corpus

• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “IL-17-deficient mice are resistant to adjuvant-induced arthritis (Nakae et al., 2003) and develop EAE with delayed onset and reduced severity (Komiyama et al.”
• Th17 cells promote cytotoxic T cell activation in tumor immunity (2009, background): “, 2001) and resistance to autoimmune diseases (Langrish et al., 2005; Nakae et al., 2003; Park et al., 2005; Yang et al., 2008).”
• IL-17 family cytokines and the expanding diversity of effector T cell lineages. (2007, background): “Consistent with this, mice with a targeted deletion of the Il17a gene alone have a profound phenotype that does not appear to be compensated by intact Il17f expression (65, 66).”
• Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides (2006, background): “For example, IL-23p19–defi cient mice are completely resistant to disease in collagen-induced arthritis, whereas IL-17A– defi cient mice remain susceptible, albeit with a signifi cantly reduced incidence and severity (9, 10).”
• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “We and others have shown that IL-17A plays important roles not only in the development of autoimmune diseases, but also in the host defense against bacteria (Mangan et al., 2006; Nakae et al., 2003; Schulz et al., 2008; Shiomi et al., 2008; Umemura et al., 2007; Ye et al., 2001).”